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MTMR4 Antikörper (C-Term)

MTMR4 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB0716 unconjugated
Produktnummer ABIN390777
  • Target Alle MTMR4 Antikörper anzeigen
    MTMR4 (Myotubularin Related Protein 4 (MTMR4))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1155-1187, C-Term
    Reaktivität
    • 37
    • 11
    • 3
    Human, Maus
    Wirt
    • 36
    • 1
    Kaninchen
    Klonalität
    • 37
    Polyklonal
    Konjugat
    • 15
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTMR4 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 23
    • 10
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.
    Klon
    RB0716
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Yu, He, Chen, Hao, Yang, Wang, Pan, Tang: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).

    Yu, Pan, Qin, Chen, Xu, Chen, Tang: "MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8454-62, (2010) (PubMed).

    Plant, Correa, Goldenberg, Bain, Batt: "The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4." in: The Biochemical journal, Vol. 419, Issue 1, pp. 57-63, (2009) (PubMed).

  • Target
    MTMR4 (Myotubularin Related Protein 4 (MTMR4))
    Andere Bezeichnung
    MTMR4 (MTMR4 Produkte)
    Synonyme
    zfyve11 antikoerper, fyve-dsp2 antikoerper, FYVE-DSP2 antikoerper, ZFYVE11 antikoerper, AA596759 antikoerper, ESTM44 antikoerper, mKIAA0647 antikoerper, myotubularin related protein 4 antikoerper, myotubularin related protein 4 L homeolog antikoerper, Mtmr4 antikoerper, MTMR4 antikoerper, mtmr4 antikoerper, mtmr4.L antikoerper
    Hintergrund
    MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47 % sequence identity with MTMR3, spiking to over 70 % identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
    Molekulargewicht
    133353
    Gen-ID
    9110
    NCBI Accession
    NP_004678
    UniProt
    Q9NYA4
    Pathways
    Inositol Metabolic Process
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