PKC epsilon Antikörper (N-Term)

Produktnummer ABIN391007

Produktdetails anti-PKC epsilon Antikörper

Target: PKC epsilon (PRKCE) (Protein Kinase C, epsilon (PRKCE))

Bindungsspezifität: AA 206-236, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKC epsilon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PKC epsilon antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the N-terminal region of human PKC epsilon.

Klon: RB1022

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PKC epsilon Antikörper (ABIN391007)

Tang, Bouyer, Mykoniatis, Buschmann, Matlin, Matthews: "Activated PKC{delta} and PKC{epsilon} inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na+-K+-2Cl- cotransporter NKCC1." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 34072-85, (2010) (PubMed).

Details zu PKC epsilon

Target: PKC epsilon (PRKCE) (Protein Kinase C, epsilon (PRKCE))

Andere Bezeichnung: PKC epsilon (PRKCE Produkte)

Synonyme: PKCE antikoerper, nPKC-epsilon antikoerper, 5830406C15Rik antikoerper, PKC[e] antikoerper, PKCepsilon antikoerper, Pkce antikoerper, R75156 antikoerper, fj59b07 antikoerper, prkce antikoerper, wu:fj59b07 antikoerper, pkce antikoerper, pkc-epsilon antikoerper, PRKCH antikoerper, protein kinase C epsilon antikoerper, protein kinase C, epsilon antikoerper, protein kinase C, epsilon a antikoerper, PRKCE antikoerper, Prkce antikoerper, prkcea antikoerper, prkce antikoerper

Hintergrund: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC epsilon is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.

Molekulargewicht: 83674

Gen-ID: 5581

NCBI Accession: NP_005391

UniProt: Q02156

Pathways: T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling