PKC iota Antikörper (N-Term)

Produktnummer ABIN391010

Produktdetails anti-PKC iota Antikörper

Target: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Bindungsspezifität: AA 176-207, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKC iota Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PKC iota antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-207 amino acids from the N-terminal region of human PKC iota.

Klon: RB01026

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PKC iota Antikörper (ABIN391010)

Lechuga, Baranwal, Ivanov: "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 308, Issue 9, pp. G745-56, (2015) (PubMed).

Wang, Li, Du, Lu, Zou: "Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma." in: The Journal of surgical research, Vol. 154, Issue 1, pp. 143-9, (2009) (PubMed).

Li, Wang, Liu, Xiao, Lu, Zou: "Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 1, pp. 70-5, (2008) (PubMed).

Details zu PKC iota

Target: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Andere Bezeichnung: PKC iota (PRKCI Produkte)

Synonyme: DXS1179E antikoerper, PKCI antikoerper, nPKC-iota antikoerper, aPKC[l] antikoerper, hal antikoerper, has antikoerper, PRKCI antikoerper, PKC antikoerper, 2310021H13Rik antikoerper, AI427505 antikoerper, PKClambda antikoerper, Pkci antikoerper, Pkcl antikoerper, Prkcl antikoerper, aPKClambda antikoerper, mKIAA4165 antikoerper, protein kinase C iota antikoerper, protein kinase C, iota antikoerper, PRKCI antikoerper, prkci antikoerper, Prkci antikoerper

Hintergrund: PKC iota belongs to the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehydes-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis.

Molekulargewicht: 68262

Gen-ID: 5584

NCBI Accession: NP_002731

UniProt: P41743

Pathways: Neurotrophin Signalübertragung, Cell-Cell Junction Organization, Tube Formation