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CERK Antikörper (C-Term)

CERK Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB5271 unconjugated
Produktnummer ABIN391126
  • Target Alle CERK Antikörper anzeigen
    CERK (Ceramide Kinase (CERK))
    Bindungsspezifität
    • 6
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 487-516, C-Term
    Reaktivität
    • 34
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 31
    • 3
    Kaninchen
    Klonalität
    • 34
    Polyklonal
    Konjugat
    • 21
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CERK Antikörper ist unkonjugiert
    Applikation
    • 19
    • 13
    • 6
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This CERK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-516 amino acids from the C-terminal region of human CERK.
    Klon
    RB5271
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CERK Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Murakami, Ito, Hagiwara, Yoshida, Sobue, Ichihara, Takagi, Kojima, Tanaka, Tamiya-Koizumi, Kyogashima, Suzuki, Banno, Nozawa, Murate: "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI." in: Journal of neurochemistry, Vol. 112, Issue 2, pp. 511-20, (2010) (PubMed).

    Yang, Gagarin, St Laurent, Hammell, Toma, Hu, Iwasa, McCaffrey: "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 8, pp. 1213-9, (2009) (PubMed).

    Hinkovska-Galcheva, Clark, VanWay, Huang, Hiraoka, Abe, Borofsky, Kunkel, Shanley, Shayman, Lanni, Petty, Boxer: "Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells." in: Journal of lipid research, Vol. 49, Issue 3, pp. 531-42, (2008) (PubMed).

  • Target
    CERK (Ceramide Kinase (CERK))
    Andere Bezeichnung
    CERK (CERK Produkte)
    Synonyme
    AI848610 antikoerper, D330016D08Rik antikoerper, mKIAA1646 antikoerper, LK4 antikoerper, dA59H18.2 antikoerper, dA59H18.3 antikoerper, hCERK antikoerper, CERK antikoerper, si:ch211-162i19.1 antikoerper, MGC81777 antikoerper, CG16708 antikoerper, DCERK antikoerper, Dcerk antikoerper, Dmel\\CG16708 antikoerper, dcerk antikoerper, ceramide kinase antikoerper, ceramide kinase S homeolog antikoerper, Ceramide kinase antikoerper, Cerk antikoerper, CERK antikoerper, cerk antikoerper, cerk.S antikoerper, CpipJ_CPIJ003342 antikoerper, LOAG_11245 antikoerper, LOC5579301 antikoerper, Bm1_50005 antikoerper
    Hintergrund
    Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart, brain, skeletal muscle, kidney and liver, moderate expression in peripheral blood leukocytes and thymus, and low expression in spleen, small intestine, placenta and lung.
    Gen-ID
    64781
    NCBI Accession
    NP_073603
    UniProt
    Q8TCT0
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