ADK Antikörper (N-Term)

Produktnummer ABIN391131

Produktdetails anti-ADK Antikörper

Target: ADK (Adenosine Kinase (ADK))

Bindungsspezifität: AA 35-65, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ADK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human ADK.

Klon: RB05253-05254

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu ADK

Target: ADK (Adenosine Kinase (ADK))

Andere Bezeichnung: ADK (ADK Produkte)

Synonyme: AK antikoerper, ADK antikoerper, DDBDRAFT_0186795 antikoerper, DDBDRAFT_0230174 antikoerper, DDB_0186795 antikoerper, DDB_0230174 antikoerper, ATPADK1 antikoerper, F3G5.4 antikoerper, F3G5_4 antikoerper, adenosine kinase antikoerper, adk antikoerper, 2310026J05Rik antikoerper, 5033405D03Rik antikoerper, AI255373 antikoerper, AI987814 antikoerper, Ak antikoerper, adenosine kinase antikoerper, ATP:adenosine 5'-phosphotransferase antikoerper, Adenosine kinase antikoerper, adenosine kinase S homeolog antikoerper, ADK antikoerper, adk antikoerper, Adk antikoerper, CNN02130 antikoerper, LOC5572668 antikoerper, CMU_026370 antikoerper, adk.S antikoerper

Hintergrund: Adenosine kinase (ATP:adenosine 5-prime-phosphotransferase) is an abundant enzyme in mammalian tissues that catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a potentially important regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of ADK could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as antiinflammatory agents. The encoded protein does not present any sequence similarities to other well-characterized mammalian nucleoside kinases. In contrast, 2 regions were identified with significant sequence identity to microbial ribokinase and fructokinases and a bacterial inosine/guanosine kinase. Thus, ADK is a structurally distinct mammalian nucleoside kinase that appears to be akin to sugar kinases of microbial origin. Animal studies have demonstrated that a deficiency of adenosine metabolism a powerful contributor to the development of neonatal hepatic steatosis, providing a model for the rapid development of postnatally lethal fatty liver.

Molekulargewicht: 40545

Gen-ID: 132

NCBI Accession: NP_001114, NP_001189378, NP_001189379, NP_006712

UniProt: P55263

Pathways: Ribonucleoside Biosynthetic Process