LRRK1 Antikörper (C-Term)

Produktnummer ABIN391141

Produktdetails anti-LRRK1 Antikörper

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Bindungsspezifität: AA 1981-2015, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This LRRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1981-2015 amino acids from the C-terminal region of human LRRK1.

Klon: RB6531

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-LRRK1 Antikörper (ABIN391141)

Toyofuku, Morimoto, Sasawatari, Kumanogoh: "Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation." in: Molecular and cellular biology, Vol. 35, Issue 17, pp. 3044-58, (2015) (PubMed).

Details zu LRRK1

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Andere Bezeichnung: LRRK1 (LRRK1 Produkte)

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Molekulargewicht: 225393

Gen-ID: 79705

NCBI Accession: NP_078928

UniProt: Q38SD2