NME3 Antikörper (AA 51-81)

Produktnummer ABIN391232

Produktdetails anti-NME3 Antikörper

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Bindungsspezifität: AA 51-81

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NME3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

Klon: RB5454

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu NME3

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Andere Bezeichnung: NME3 (NME3 Produkte)

Synonyme: DR-nm23 antikoerper, NDPK-C antikoerper, NDPKC antikoerper, NM23-H3 antikoerper, NM23H3 antikoerper, c371H6.2 antikoerper, 1810009F08Rik antikoerper, AI413736 antikoerper, Ndk3 antikoerper, Nm23-DR antikoerper, Nm23-M3 antikoerper, NME/NM23 nucleoside diphosphate kinase 3 antikoerper, NME3 antikoerper, Nme3 antikoerper

Hintergrund: NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

Molekulargewicht: 19015

Gen-ID: 4832

NCBI Accession: NP_002504

UniProt: Q13232

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process