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CDK2 Antikörper (C-Term)

Name: CDK2 Antikörper (C-Term)
SKU: ABIN391746
Price: 510 EUR
Availability: InStock

CDK2 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB3128 unconjugated

Western blot analysis of anti-CDK2 Antibody (C-term) (ABIN391746 and ABIN2841622) in Jurkat cell line lysates (35 μg/lane). (CDK2 Antikörper (C-Term))

Flow cytometric analysis of jurkat cells using CDK2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). (CDK2 Antikörper (C-Term))

FACS

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with CDK2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (CDK2 Antikörper (C-Term))

IHC (p)

3 Abbildungen

(1 reference)

Produktnummer ABIN391746

Datenblatt (PDF)

Target Alle CDK2 Antikörper anzeigen

CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
Bindungsspezifität
28

27

18

16

15

10

9

8

7

6

5

5

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 230-260, C-Term
Reaktivität
186

106

86

11

10

8

8

8

7

6

6

6

4

3

3

3

2
Human
Wirt
187

21

1
Kaninchen
Passende Sekundärantikörper
Klonalität
178

31
Polyklonal
Konjugat
99

17

15

10

7

5

4

4

4

4

4

4

4

4

4

4

4

2

2

2

2

2

2
Dieser CDK2 Antikörper ist unkonjugiert
Applikation
170

76

52

49

49

39

26

22

21

12

10

8

5

3

2

2

2

2

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie

B, Ha, M, Rat, X

Aufreinigung

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen

This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the C-terminal region of human CDK2.

Klon

RB3128

Isotyp

Ig Fraction

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anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 93-211) antibody
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anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) antibody
CDK2 Reaktivität: Human WB, PLA Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Zang, Zhang, Gao, Huang: "Ophiopogonin D inhibits cell proliferation, causes cell cycle arrest at G2/M, and induces apoptosis in human breast carcinoma MCF-7 cells." in: Journal of integrative medicine, Vol. 14, Issue 1, pp. 51-9, (2016) (PubMed).
Target

CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Andere Bezeichnung

CDK2 (CDK2 Produkte)

Synonyme

p33(CDK2) antikoerper, A630093N05Rik antikoerper, wu:fa10c02 antikoerper, zgc:56598 antikoerper, zgc:77684 antikoerper, eg1 antikoerper, CDKN2 antikoerper, cdk2L antikoerper, cyclin dependent kinase 2 antikoerper, cyclin-dependent kinase 2 antikoerper, cyclin-dependent kinase 2 S homeolog antikoerper, CDK2 antikoerper, Cdk2 antikoerper, cdk2 antikoerper, cdk2.S antikoerper

Hintergrund

CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.

Molekulargewicht

33930

Gen-ID

1017

NCBI Accession

NP_001789, NP_439892

UniProt

P24941

Pathways

PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA