Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PUM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-162 amino acids from the N-terminal region of human PUM2.
pum-2 antikoerper, 5730503J23Rik antikoerper, Pumm2 antikoerper, mKIAA0235 antikoerper, PUMH2 antikoerper, PUML2 antikoerper, pumilio RNA binding family member 2 antikoerper, pumilio RNA-binding family member 2 antikoerper, pum2 antikoerper, Pum2 antikoerper, PUM2 antikoerper
Hintergrund
PUM2 is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of this protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation.