EPH Receptor B4 Antikörper

Produktnummer ABIN391924

Produktdetails anti-EPH Receptor B4 Antikörper

Target: EPH Receptor B4 (EPHB4)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphB4 antibody is generated from rabbits immunized with human recombinant EphB4 protein.

Klon: RB14731

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-EPH Receptor B4 Antikörper (ABIN391924)

Aslam, Abraham, Mansoor, Druker, Tyner, Keller: "PDGFR? reverses EphB4 signaling in alveolar rhabdomyosarcoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 17, pp. 6383-8, (2014) (PubMed).

Brantley-Sieders, Jiang, Sarma, Badu-Nkansah, Walter, Shyr, Chen: "Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome." in: PLoS ONE, Vol. 6, Issue 9, pp. e24426, (2011) (PubMed).

Details zu EPH Receptor B4

Target: EPH Receptor B4 (EPHB4)

Andere Bezeichnung: EphB4 (EPHB4 Produkte)

Synonyme: HTK antikoerper, MYK1 antikoerper, TYRO11 antikoerper, htk antikoerper, myk1 antikoerper, ephB4a antikoerper, tyro11 antikoerper, ephb4b antikoerper, MGC130997 antikoerper, AI042935 antikoerper, Htk antikoerper, MDK2 antikoerper, Myk1 antikoerper, Tyro11 antikoerper, cb646 antikoerper, ephB4 antikoerper, rtk5 antikoerper, EphB-rtk8 antikoerper, cb417 antikoerper, rtk8 antikoerper, EPH receptor B4 antikoerper, EPH receptor B4 L homeolog antikoerper, EPH receptor B4 S homeolog antikoerper, Eph receptor B4 antikoerper, eph receptor B4a antikoerper, eph receptor B4b antikoerper, EPHB4 antikoerper, ephb4.L antikoerper, ephb4.S antikoerper, ephb4 antikoerper, Ephb4 antikoerper, ephb4a antikoerper, ephb4b antikoerper

Hintergrund: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Molekulargewicht: 108270

Gen-ID: 2050

NCBI Accession: NP_004435

UniProt: P54760

Pathways: RTK Signalweg