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RYK Antikörper (AA 160-190)

RYK Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal RB1491 unconjugated
Produktnummer ABIN392050
  • Target Alle RYK Antikörper anzeigen
    RYK (RYK Receptor-Like Tyrosine Kinase (RYK))
    Bindungsspezifität
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 160-190
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 60
    • 13
    • 3
    • 1
    Kaninchen
    Klonalität
    • 66
    • 11
    Polyklonal
    Konjugat
    • 32
    • 8
    • 8
    • 7
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RYK Antikörper ist unkonjugiert
    Applikation
    • 65
    • 49
    • 32
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This RYK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from human RYK.
    Klon
    RB1491
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Haltbarkeit
    6 months
  • Povinelli, Nemeth: "Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor." in: Stem cells (Dayton, Ohio), Vol. 32, Issue 1, pp. 105-15, (2014) (PubMed).

    González, Fernández-Martos, Arenas, Rodríguez: "The Ryk receptor is expressed in glial and fibronectin-expressing cells after spinal cord injury." in: Journal of neurotrauma, Vol. 30, Issue 10, pp. 806-17, (2013) (PubMed).

    Santiago, Oguma, Brown, Laurence: "Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 223-30, (2012) (PubMed).

    Miyashita, Koda, Kitajo, Yamazaki, Takahashi, Kikuchi, Yamashita: "Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury." in: Journal of neurotrauma, Vol. 26, Issue 7, pp. 955-64, (2009) (PubMed).

  • Target
    RYK (RYK Receptor-Like Tyrosine Kinase (RYK))
    Andere Bezeichnung
    RYK (RYK Produkte)
    Synonyme
    RYK antikoerper, jtk5 antikoerper, ryk1 antikoerper, jtk5a antikoerper, d3s3195 antikoerper, wu:fb37b12 antikoerper, wu:fi05b06 antikoerper, zgc:158381 antikoerper, MGC114645 antikoerper, D3S3195 antikoerper, JTK5 antikoerper, JTK5A antikoerper, RYK1 antikoerper, AW536699 antikoerper, ERK-3 antikoerper, Vik antikoerper, receptor-like tyrosine kinase antikoerper, receptor-like tyrosine kinase S homeolog antikoerper, tyrosine-protein kinase RYK antikoerper, RYK antikoerper, ryk antikoerper, ryk.S antikoerper, LOC100541106 antikoerper, Ryk antikoerper
    Hintergrund
    RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
    Molekulargewicht
    67815
    Gen-ID
    6259
    NCBI Accession
    NP_001005861, NP_002949
    UniProt
    P34925
    Pathways
    RTK Signalweg, WNT Signalweg, Regulation of Cell Size
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