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BTK Antikörper (AA 209-239)

BTK Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB03117 unconjugated
Produktnummer ABIN392089
  • Target Alle BTK Antikörper anzeigen
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Bindungsspezifität
    • 42
    • 16
    • 15
    • 14
    • 12
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 209-239
    Reaktivität
    • 143
    • 95
    • 78
    • 14
    • 6
    • 4
    • 2
    Human
    Wirt
    • 158
    • 16
    Kaninchen
    Klonalität
    • 148
    • 27
    Polyklonal
    Konjugat
    • 66
    • 14
    • 10
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser BTK Antikörper ist unkonjugiert
    Applikation
    • 108
    • 64
    • 43
    • 40
    • 40
    • 18
    • 18
    • 15
    • 10
    • 10
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This BTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human BTK.
    Klon
    RB03117
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product BTK Primärantikörper
  • Applikationshinweise
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Andere Bezeichnung
    BTK (BTK Produkte)
    Synonyme
    BTK antikoerper, atk antikoerper, bpk antikoerper, xla antikoerper, imd1 antikoerper, agmx1 antikoerper, psctk1 antikoerper, AGMX1 antikoerper, AT antikoerper, ATK antikoerper, BPK antikoerper, IMD1 antikoerper, PSCTK1 antikoerper, XLA antikoerper, AI528679 antikoerper, xid antikoerper, Bruton tyrosine kinase antikoerper, Bruton agammaglobulinemia tyrosine kinase antikoerper, BTK antikoerper, btk antikoerper, Btk antikoerper
    Hintergrund
    BTK plays a crucial role in B-cell ontogeny. This protein transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Defects in BTK are the cause of X-linked agammaglobulinemia type 1 (XLA). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis or fatal sepsis or meningitis within the first years of life.
    Molekulargewicht
    76281
    Gen-ID
    695
    NCBI Accession
    NP_000052
    UniProt
    Q06187
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
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