TRIB1 Antikörper (C-Term)

Produktnummer ABIN392118

Produktdetails anti-TRIB1 Antikörper

Target: TRIB1 (Tribbles Homolog 1 (TRIB1))

Bindungsspezifität: AA 341-370, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TRIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TRIB1.

Klon: RB9762

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:2000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-TRIB1 Antikörper (ABIN392118)

Makishima, Boonvisut, Ishizuka, Watanabe, Nakayama, Iwamoto: "Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression." in: Journal of lipid research, Vol. 56, Issue 6, pp. 1145-52, (2015) (PubMed).

Ishizuka, Nakayama, Ogawa, Makishima, Boonvisut, Hirao, Iwasaki, Yada, Yanagisawa, Miyashita, Takahashi, Iwamoto: "TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions." in: Journal of molecular endocrinology, Vol. 52, Issue 2, pp. 145-58, (2014) (PubMed).

Dugast, Kiss-Toth, Docherty, Danger, Chesneau, Pichard, Judor, Pettré, Conchon, Soulillou, Brouard, Ashton-Chess: "Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells." in: The Journal of biological chemistry, Vol. 288, Issue 14, pp. 10051-60, (2013) (PubMed).

Details zu TRIB1

Target: TRIB1 (Tribbles Homolog 1 (TRIB1))

Andere Bezeichnung: TRIB1 (TRIB1 Produkte)

Hintergrund: TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.

Molekulargewicht: 41009

Gen-ID: 10221

NCBI Accession: NP_079471

UniProt: Q96RU8

Pathways: Smooth Muscle Cell Migration