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alpha Actinin 4 Antikörper (C-Term)

Name: alpha Actinin 4 Antikörper (C-Term)
SKU: ABIN392219
Price: 445.5 EUR
Availability: InStock

ACTN4 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB15705 unconjugated

Western blot analysis of ACTN4 Antibody (C-term) (ABIN392219 and ABIN2841915) in T47D, , , HepG2 cell line and mouse bladder tissue lysates (35 μg/lane). (alpha Actinin 4 Antikörper (C-Term))

Flow cytometric analysis of MDA-231 cells using ACTN4 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). (alpha Actinin 4 Antikörper (C-Term))

FACS

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with ACTN4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (alpha Actinin 4 Antikörper (C-Term))

IHC (p)

3 Abbildungen

(1 reference)

Produktnummer ABIN392219

Datenblatt (PDF)

Target Alle alpha Actinin 4 (ACTN4) Antikörper anzeigen

alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
Bindungsspezifität
10

6

6

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 785-813, C-Term
Reaktivität
91

50

46

8

5

4

4

3

3

3

2

2

1

1

1
Human
Wirt
84

7
Kaninchen
Passende Sekundärantikörper
Klonalität
72

18
Polyklonal
Konjugat
55

6

6

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
Dieser alpha Actinin 4 Antikörper ist unkonjugiert
Applikation
68

31

26

17

15

14

14

12

8

2

2

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen

This ACTN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 785-813 amino acids from the C-terminal region of human ACTN4.

Klon

RB15705

Isotyp

Ig Fraction

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anti-Actinin, alpha 4 (ACTN4) (AA 561-661) antibody
ACTN4 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

anti-Actinin, alpha 4 (ACTN4) (C-Term) antibody
ACTN4 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Wang, Li, Wang, Tan, Jia, Yang, Li, Shang, Xu, Yang, Shoyama, Cai: "Alpha-Actinin-4 is a Possible Target Protein for Aristolochic Acid I in Human Kidney Cells In Vitro." in: The American journal of Chinese medicine, Vol. 44, Issue 2, pp. 291-304, (2016) (PubMed).
Target

alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Andere Bezeichnung

ACTN4 (ACTN4 Produkte)

Synonyme

fsgs antikoerper, fsgs1 antikoerper, C77391 antikoerper, ACTININ-4 antikoerper, FSGS antikoerper, FSGS1 antikoerper, wu:fb53f05 antikoerper, zgc:63508 antikoerper, actinin alpha 4 antikoerper, actinin, alpha 4 antikoerper, actinin alpha 4 S homeolog antikoerper, actn4 antikoerper, ACTN4 antikoerper, Actn4 antikoerper, actn4.S antikoerper

Hintergrund

Alpha actinins belong to the spectrin superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This protein is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and is thought to be involved in metastatic processes. Mutations in the gene encoding this protein have been associated with focal and segmental glomerulosclerosis.

Molekulargewicht

104854

Gen-ID

81

NCBI Accession

NP_004915

UniProt

O43707

Pathways

Proton Transport