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PIK3R3 Antikörper (C-Term)

PIK3R3 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB1719 unconjugated
Produktnummer ABIN392576
  • Target Alle PIK3R3 Antikörper anzeigen
    PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3))
    Bindungsspezifität
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 316-346, C-Term
    Reaktivität
    • 45
    • 34
    • 18
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 40
    • 4
    • 1
    • 1
    Kaninchen
    Klonalität
    • 36
    • 10
    Polyklonal
    Konjugat
    • 27
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser PIK3R3 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 16
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PIK3R3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-346 amino acids from the C-terminal region of human PIK3R3.
    Klon
    RB1719
    Isotyp
    Ig Fraction
  • Applikationshinweise
    IF: 1:100. WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Yang, Cheng, Zhou, Zhu, Hu, Yang: "Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma." in: International journal of molecular sciences, Vol. 16, Issue 12, pp. 28635-46, (2016) (PubMed).

    Wang, Yang, Jin, Deng, Luo, Hu, Wang: "TGF-? regulates the proliferation of lung adenocarcinoma cells by inhibiting PIK3R3 expression." in: Molecular carcinogenesis, (2014) (PubMed).

    Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

    Zhang, Huang, Yang, Greshock, Liang, Hasegawa, Giannakakis, Poulos, OBrien-Jenkins, Katsaros, Butzow, Weber, Coukos: "Integrative genomic analysis of phosphatidylinositol 3'-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 18 Pt 1, pp. 5314-21, (2007) (PubMed).

  • Target
    PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3))
    Andere Bezeichnung
    PIK3R3 (PIK3R3 Produkte)
    Synonyme
    AA414954 antikoerper, p55pik antikoerper, p55 antikoerper, p55-GAMMA antikoerper, pik3r3 antikoerper, zgc:55564 antikoerper, zgc:85710 antikoerper, phosphoinositide-3-kinase regulatory subunit 3 antikoerper, phosphoinositide-3-kinase, regulatory subunit 3 (gamma) antikoerper, phosphoinositide-3-kinase, regulatory subunit 3b (gamma) antikoerper, PIK3R3 antikoerper, Pik3r3 antikoerper, pik3r3b antikoerper
    Hintergrund
    PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.
    Molekulargewicht
    54448
    Gen-ID
    8503
    NCBI Accession
    NP_001107644, NP_003620
    UniProt
    Q92569
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