Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This MOS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MOS.
MOS antikoerper, c-mos antikoerper, msv antikoerper, p39 antikoerper, mosxe antikoerper, MSV antikoerper, p39-mos antikoerper, MOS proto-oncogene, serine/threonine kinase antikoerper, v-mos Moloney murine sarcoma viral oncogene homolog antikoerper, serine/threonine-protein kinase mos-like antikoerper, Moloney sarcoma oncogene antikoerper, MOS proto-oncogene, serine/threonine kinase L homeolog antikoerper, MOS antikoerper, mos antikoerper, LOC100229612 antikoerper, Mos antikoerper, mos.L antikoerper
Hintergrund
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.