SIK1 Antikörper (C-Term)

Produktnummer ABIN392683

Produktdetails anti-SIK1 Antikörper

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Bindungsspezifität: AA 567-597, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SNF1LK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-597 amino acids from the C-terminal region of human SNF1LK.

Klon: RB3576

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-SIK1 Antikörper (ABIN392683)

Cheng, Liu, Wang, Zou, Santiago, Garbitt, Gjoerup, Iglehart, Miron, Richardson, Hahn, Zhao: "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis." in: Science signaling, Vol. 2, Issue 80, pp. ra35, (2009) (PubMed).

Details zu SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Andere Bezeichnung: SNF1LK (SIK1 Produkte)

Synonyme: Msk antikoerper, Sik antikoerper, Snf1lk antikoerper, SIK2 antikoerper, SNF1LK antikoerper, MSK antikoerper, SIK antikoerper, salt-inducible kinase 1 antikoerper, salt inducible kinase 1 antikoerper, SIK1 antikoerper, Sik1 antikoerper

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Molekulargewicht: 84902

Gen-ID: 150094

NCBI Accession: NP_775490

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process