TLK2 Antikörper (AA 141-171)

Produktnummer ABIN392686

Produktdetails anti-TLK2 Antikörper

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Bindungsspezifität: AA 141-171

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-171 amino acids from the Central region of human TLK2.

Klon: RB3046

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu TLK2

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Andere Bezeichnung: TLK2 (TLK2 Produkte)

Synonyme: tlk2 antikoerper, MGC149057 antikoerper, HsHPK antikoerper, PKU-ALPHA antikoerper, wu:fi16h09 antikoerper, wu:fi30g12 antikoerper, zgc:136697 antikoerper, 4933403M19Rik antikoerper, PKUalpha antikoerper, Tlk antikoerper, tousled like kinase 2 antikoerper, tousled-like kinase 2 antikoerper, tousled-like kinase 2 (Arabidopsis) antikoerper, tlk2 antikoerper, TLK2 antikoerper, Tlk2 antikoerper

Hintergrund: TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Molekulargewicht: 87661

Gen-ID: 11011

NCBI Accession: NP_001106178, NP_006843

UniProt: Q86UE8