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HK3 Antikörper (C-Term)

HK3 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB3916 unconjugated
Produktnummer ABIN392753
  • Target Alle HK3 Antikörper anzeigen
    HK3 (Hexokinase 3 (White Cell) (HK3))
    Bindungsspezifität
    • 10
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 760-789, C-Term
    Reaktivität
    • 51
    • 4
    • 2
    Human, Maus
    Wirt
    • 48
    • 4
    Kaninchen
    Klonalität
    • 50
    • 2
    Polyklonal
    Konjugat
    • 26
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HK3 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 28
    • 22
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HK3 (Hexokinase III) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 760-789 amino acids from the C-terminal region of human HK3 (Hexokinase III).
    Klon
    RB3916
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • van der Kooij, Rojas-Charry, Givehchi, Wolf, Bueno, Arndt, Tenzer, Mattioni, Treccani, Hasch, Schmeisser, Vianello, Giacomello, Methner: "Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels." in: Journal of molecular medicine (Berlin, Germany), Vol. 100, Issue 10, pp. 1441-1453, (2022) (PubMed).

    Palmieri, Fitzgerald, Shreeve, Hua, Bronder, Weil, Davis, Stark, Merino, Kurek, Mehdorn, Davis, Steinberg, Meltzer, Aldape, Steeg: "Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis." in: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1438-45, (2009) (PubMed).

  • Target
    HK3 (Hexokinase 3 (White Cell) (HK3))
    Andere Bezeichnung
    HK3 (Hexokinase III) (HK3 Produkte)
    Synonyme
    HKIII antikoerper, HXK3 antikoerper, APS antikoerper, KLK2A1 antikoerper, PSA antikoerper, hK3 antikoerper, HK III antikoerper, HK-III antikoerper, T2E6.5 antikoerper, T2E6_5 antikoerper, hexokinase 3 antikoerper, RNU73859 antikoerper, hexokinase 3 antikoerper, kallikrein related peptidase 3 antikoerper, HK3 antikoerper, KLK3 antikoerper, Hk3 antikoerper, HXK3 antikoerper
    Hintergrund
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
    Molekulargewicht
    99025
    Gen-ID
    3101
    NCBI Accession
    NP_002106
    UniProt
    P52790
    Pathways
    Carbohydrate Homeostasis, Warburg Effekt
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