DUSP14 Antikörper (N-Term)

Produktnummer ABIN392877

Produktdetails anti-DUSP14 Antikörper

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This DUSP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP14.

Klon: RB5911

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu DUSP14

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Andere Bezeichnung: DUSP14 (DUSP14 Produkte)

Synonyme: MGC84083 antikoerper, zgc:101746 antikoerper, DUSP14 antikoerper, mkp-l antikoerper, mkp6 antikoerper, MKP-L antikoerper, MKP6 antikoerper, 1110014C10Rik antikoerper, 2310042C07Rik antikoerper, D11Ertd395e antikoerper, Mkp6 antikoerper, dual specificity phosphatase 14 antikoerper, dual specificity phosphatase 14 L homeolog antikoerper, DUSP14 antikoerper, dusp14.L antikoerper, dusp14 antikoerper, Dusp14 antikoerper

Hintergrund: DUSP14 is involved in the inactivation of MAP kinases. This protein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 and B7-2 ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.

Molekulargewicht: 22255

Gen-ID: 11072

NCBI Accession: NP_008957

UniProt: O95147