NIPBL Antikörper (AA 344-356)

Produktnummer ABIN401167

Produktdetails anti-NIPBL Antikörper

Target: NIPBL (Nipped-B like Protein (NIPBL))

Bindungsspezifität: AA 344-356

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Orang-Utan

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser NIPBL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody is directed against IDN3 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Mouse, Canine, Bovine, Orangutan.
Species reactivity (tested):Human.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide corresponding to amino acids 344-356 of Human IDN3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/2000 - 1/10000. Western Blot: 1/500 - 1/3000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.6 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu NIPBL

Target: NIPBL (Nipped-B like Protein (NIPBL))

Andere Bezeichnung: NIPBL (NIPBL Produkte)

Hintergrund: IDN3 (also known as Colon tumor susceptibility 2, DKFZp434L1319, FLJ13648, Mis 4, Scc-2, Delangin and Sister chromatid cohesion protein) is the mammalian homologue of Scc2 in S. cerevisiae and Mis4 in S. pombe. In yeast, this factor was originally identified genetically as being involved in sister chromatid cohesion, subsequent work has determined that it is not involved in cohesion directly but is required for the loading of cohesins onto chromatin during S phase. It shares 37 % sequence identity with Nipped-B gene product of Drosophila, which facilitates enhancerpromoter communication of remote enhancers. The Drosophila protein is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. IDN3 is a nuclear protein that is widely expressed and found at the highest levels in heart, skeletal muscle, fetal and adult liver, and fetal and adult kidney. The protein is also found, albeit at lower levels of expression in thymus, placenta, peripheral leukocyte and small intestine. Multiple isoforms of the protein have been reported.Synonyms: Delangin, IDN3, Nipped-B-like protein, SCC2 homolo

Gen-ID: 25836

NCBI Accession: NP_056199

UniProt: Q6KC79

Pathways: Sensory Perception of Sound, Stem Cell Maintenance