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EGFR Antikörper (AA 1189-1199)

Name: EGFR Antikörper (AA 1189-1199)
SKU: ABIN401323
Price: 1411.53 EUR
Availability: InStock

EGFR Reaktivität: Human, Maus, Ratte WB, EIA Wirt: Kaninchen Polyclonal unconjugated

Image no. 1 for anti-Epidermal Growth Factor Receptor (EGFR) (AA 1189-1199) antibody (ABIN401323) (EGFR Antikörper (AA 1189-1199))

1 image

Produktnummer ABIN401323

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Bindungsspezifität
39

38

31

31

30

28

27

26

25

22

21

18

16

16

16

15

15

15

11

11

10

9

9

9

8

8

7

6

5

5

5

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3
AA 1189-1199
Reaktivität
762

299

287

25

25

24

20

14

8

3

2

2

1

1

1

1

1

1
Human, Maus, Ratte
Wirt
581

178

14

13

5

4

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
543

249

2
Polyklonal
Konjugat
416

58

29

22

20

18

18

17

16

16

16

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
538

252

154

151

128

102

99

93

82

46

37

34

34

19

11

8

6

5

4

4

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität

This antibody is directed against epidermal growth factor receptor (EGFR)

Aufreinigung

Affinity chromatography

Immunogen

Synthetic peptide corresponding to amino acids 1189-1199 of human EGFR protein

Isotyp

IgG

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anti-Epidermal Growth Factor Receptor (EGFR) (pSer1071) antibody
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anti-Epidermal Growth Factor Receptor (EGFR) (pSer695) antibody
EGFR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 1021-1210) antibody
EGFR Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibody
EGFR Reaktivität: Human, Ratte WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

ELISA: 1/8,000 - 1/32,000. Western Blot 1/500 - 1/5,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL (by UV absorbance at 280 nm)

Buffer

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Avoid repeated freezing and thawing.

Lagerung

-20 °C
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR / ERBB1 (EGFR Produkte)

Hintergrund

EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. Growth factor receptors are involved not only in promoting the proliferation of normal cells but also in the aberrant growth of many types of human tumors. For example, the epidermal growth factor receptor (EGFR) is mutated and/or overexpressed in many common solid human squamous cell carcinomas including breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. Overexpression of the EGFR gene occurs in carcinomas with and without gene amplification. EGFR and erbB-2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. EGFR belongs to a family of growth factor receptors, which also includes ErbB-2/HER-2/neu, ErbB-3/HER-3/neu and ErbB-4/HER-4neu. EGFR can heterodimerize with each of the members of this family.Synonyms: EGF Receptor, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, c-ErbB-1, erbB-1

Gen-ID

1956

NCBI Accession

NP_005219

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine