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MTOR Antikörper (Ser2481)
mTOR
Reaktivität: Human, Maus, Ratte
IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-MTOR Antikörper
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Target
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MTOR (mTOR)
(Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
Bindungsspezifität
Alle Epitope für MTOR Antikörper
Ser2481
Reaktivität
Alle Reaktivitäten für MTOR Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für MTOR Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für MTOR Antikörper
Polyklonal
Konjugat
Alle Konjugate für MTOR Antikörper
Dieser MTOR Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MTOR Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
MTOR Antibody detects endogenous levels of total mTOR protein.
Aufreinigung
Affinity chromatography
Immunogen
Synthesized non-phosphopeptide derived from human mTOR around the phosphorylation site of serine 2481 (I-H-SP-F-I).
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Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Details zu MTOR
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Target
MTOR (mTOR)
(Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
Andere Bezeichnung
mTOR / FRAP1 (mTOR Produkte )
Synonyme
FRAP1 antikoerper, FRAP antikoerper, FRAP2 antikoerper, RAFT1 antikoerper, RAPT1 antikoerper, 2610315D21Rik antikoerper, AI327068 antikoerper, Frap1 antikoerper, flat antikoerper, frap1 antikoerper, tor antikoerper, wu:fc22h08 antikoerper, mechanistic target of rapamycin kinase antikoerper, mechanistic target of rapamycin antikoerper, mechanistic target of rapamycin (serine/threonine kinase) antikoerper, MTOR antikoerper, Mtor antikoerper, mtor antikoerper
Hintergrund
MTOR, or FKBP12 rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289- kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.Synonyms: FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, FRAP, FRAP2, Mammalian target of rapamycin, RAPT1, Rapamycin target protein, Serine/threonine-protein kinase mTOR, TOR
Gen-ID
2475
NCBI Accession
NP_004949
UniProt
P42345
Pathways
PI3K-Akt Signalweg , RTK Signalweg , AMPK Signaling , Interferon-gamma Pathway , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Regulation of Actin Filament Polymerization , Regulation of Muscle Cell Differentiation , Regulation of Cell Size , Skeletal Muscle Fiber Development , Regulation of Carbohydrate Metabolic Process , Autophagie , CXCR4-mediated Signaling Events , BCR Signaling , Warburg Effekt
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