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PRR7 Antikörper (C-Term, Intracellular)

PRR7 Reaktivität: Human, Maus, Ratte WB, ICC Wirt: Maus Monoclonal TRAP3-10 unconjugated
Produktnummer ABIN457438
  • Target Alle PRR7 Antikörper anzeigen
    PRR7 (Proline Rich 7 (Synaptic) (PRR7))
    Bindungsspezifität
    • 9
    • 8
    • 7
    • 1
    • 1
    • 1
    C-Term, Intracellular
    Reaktivität
    • 20
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 18
    • 2
    Maus
    Klonalität
    • 18
    • 2
    Monoklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PRR7 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 13
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC)
    Spezifität
    The mouse monoclonal antibody TRAP3/10 recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126-253 of human PRR7 / TRAP3), a 28 kDa proline-rich membrane protein presumably associated with NMDA receptor complex.
    Kreuzreaktivität (Details)
    Human, Mouse, Rat
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
    Klon
    TRAP3-10
    Isotyp
    IgG2a
  • Applikationshinweise
    Immunocytochemistry: Recommended dilution: 10 μg/mL, cell culture fixed with 4 % paraformaldehyde, permeabilized with 0.1 % Triton-X100.
    Western blotting: Recommended dilution: 1 μg/mL, positive control: murine brain lysate (red. Laemmli buffer).
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

  • Target
    PRR7 (Proline Rich 7 (Synaptic) (PRR7))
    Andere Bezeichnung
    PRR7 / TRAP3 (PRR7 Produkte)
    Synonyme
    PRR7 antikoerper, XM_484263 antikoerper, proline rich 7, synaptic antikoerper, proline rich 7 (synaptic) antikoerper, proline rich 7 (synaptic) L homeolog antikoerper, PRR7 antikoerper, prr7 antikoerper, prr7.L antikoerper, Prr7 antikoerper
    Hintergrund
    Proline rich 7, synaptic,PRR7/TRAP3 (proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein ubiquitously expressed at low level (most in brain). Its amino acid sequence is extremely conserved among mammalian and other species. PRR7/TRAP3 contains potential palmitoylation motif and is found in lipid rafts. It is a part of the complex postsynaptic density fraction in neurons and associates with PSD-95, NMDA receptor and probably other proteins. The intracellular domain of PRR7/TRAP3 contains several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif. So far nothing is known about function of this protein. It may be involved in regulation of some receptor signaling and in formation of neurologic and immunologic synapse.,TRAP3
    Gen-ID
    80758
    UniProt
    Q8TB68
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