ELOVL4 Antikörper

Produktnummer ABIN4620376

Produktdetails anti-ELOVL4 Antikörper

Target: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELOVL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects ELOV4, expressed in the retina and at much lower level in the brain.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptdide derived from the human ELOV4 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot (1: 400 starting dilution).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Details zu ELOVL4

Target: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Andere Bezeichnung: ELOVL4 (ELOVL4 Produkte)

Hintergrund: Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. Elovl4 is expressed in the retina and only a limited number of mammalian other tissues, including skin, with unknown function. In a mouse model with the 5-bp deletion in the Elovl4 gene, mice in the heterozygous state (Elovl4(+/del)) demonstrate progressive photoreceptor degeneration. Homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Lipid analyses of epidermis from Elovl4(del/del) mice show a decrease in very long-chain fatty acids (VLFAs) in both the ceramide/glucosylceramide and the free fatty-acid fractions. ELOVL4 is required for generating VLFA critical for epidermal barrier function.Synonyms: 3-keto acyl-CoA synthase ELOVL4, Elongation of very long chain fatty acids protein 4

Gen-ID: 6785

NCBI Accession: NP_073563

UniProt: Q9GZR5