Reaktivität: Diverse Spezies
ELISA, AP, IA
Wirt: Schaf
Polyclonal
unconjugated
Applikationshinweise
ELISA: 0.039 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
10.20 mg/mL (U.V.abs at 280nm)
Buffer
20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody (in aliquots) at-20 °C.
Target
Gestrinone
Substanzklasse
Hormone
Hintergrund
Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10 % of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.(1) It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.(1) It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.(2) Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.(3) These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.(3)Synonyms: Dimetriose, Dimetrose, Ethylnorgestrienone, Gestrigone, Gestrinonum, Nemestran, Tridomose