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Methotrexate Antikörper

MTX EIA Wirt: Schaf Polyclonal unconjugated
Produktnummer ABIN487772
  • Target Alle Methotrexate (MTX) Antikörper anzeigen
    Methotrexate (MTX)
    Reaktivität
    Bitte anfragen
    Wirt
    • 3
    Schaf
    Klonalität
    • 2
    Polyklonal
    Konjugat
    • 3
    Dieser Methotrexate Antikörper ist unkonjugiert
    Applikation
    • 3
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    Aufreinigung
    Ig Fraction
    Immunogen
    Methotrexate -BSA
    Isotyp
    IgG
    Top Product
    Discover our top product MTX Primärantikörper
  • Applikationshinweise
    ELISA: 2.5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    7.74 mg/mL (U.V.abs at 280nm)
    Buffer
    20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
  • Target
    Methotrexate (MTX)
    Andere Bezeichnung
    Methotrexate (MTX Produkte)
    Substanzklasse
    Amino Acid
    Hintergrund
    Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.Synonyms: 4-amino-10-methylpteroyl-L-glutamic acid
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