ADC Antikörper (AA 111-301)

Produktnummer ABIN4886479

Produktdetails anti-ADC Antikörper

Target: ADC (Arginine Decarboxylase (ADC))

Bindungsspezifität: AA 111-301

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Antizyme inhibitor 2(AZIN2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Antizyme inhibitor 2(AZIN2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: antizyme inhibitor 2
Protein Name: Antizyme inhibitor 2

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human AZIN2 recombinant protein (Position: C111-Q301). Human AZIN2 shares 89.4% amino acid (aa) sequence identity with mouse AZIN2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu ADC

Target: ADC (Arginine Decarboxylase (ADC))

Andere Bezeichnung: AZIN2 (ADC Produkte)

Synonyme: MGC134604 antikoerper, azi2 antikoerper, odc2 antikoerper, odc-p antikoerper, odc1l antikoerper, xodc2 antikoerper, ADC antikoerper, AZI2 antikoerper, ODC-p antikoerper, ODC1L antikoerper, 4933429I20Rik antikoerper, AZIN2 antikoerper, Azi2 antikoerper, B930082O19 antikoerper, Odcp antikoerper, RGD1564776 antikoerper, odc1-b antikoerper, arginine decarboxylase antikoerper, antizyme inhibitor 2 antikoerper, biosynthetic arginine decarboxylase SpeA antikoerper, biosynthetic arginine decarboxylase SpeA (ADC) antikoerper, pyruvoyl-dependent arginine decarboxylase antikoerper, antizyme inhibitor 2 S homeolog antikoerper, AZIN2 antikoerper, azin2 antikoerper, adc antikoerper, speA antikoerper, Mrub_2839 antikoerper, MMAH_RS09440 antikoerper, Arnit_1968 antikoerper, Mesil_3114 antikoerper, Trad_0080 antikoerper, Spirs_3255 antikoerper, LOC100233080 antikoerper, Azin2 antikoerper, azin2.S antikoerper

Hintergrund: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

Synonyms: ADC | Antizyme inhibitor 2 | ArgDC | Arginine decarboxylase | AZI2 | ODC-p | ODC-paralogue | ODC1L | ODCp | Q96A70

Gen-ID: 113451

UniProt: Q96A70