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FCAR Antikörper

FCAR Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal A59 unconjugated
Produktnummer ABIN4888509
  • Target Alle FCAR Antikörper anzeigen
    FCAR (Fc Fragment of IgA, Receptor For (FCAR))
    Reaktivität
    • 67
    • 21
    • 9
    • 3
    • 3
    Human, Non-Human Primate
    Wirt
    • 49
    • 23
    Maus
    Klonalität
    • 50
    • 21
    • 1
    Monoklonal
    Konjugat
    • 30
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FCAR Antikörper ist unkonjugiert
    Applikation
    • 27
    • 26
    • 19
    • 13
    • 13
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Ag8.653 myeloma cells
    Klon
    A59
    Isotyp
    IgG1 kappa
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  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Target
    FCAR (Fc Fragment of IgA, Receptor For (FCAR))
    Andere Bezeichnung
    CD89 (FCAR Produkte)
    Synonyme
    CD89 antikoerper, Fc fragment of IgA receptor antikoerper, Fc fragment of IgA, receptor for antikoerper, FCAR antikoerper
    Hintergrund
    Fc fragment of IgA receptor,CD89 (Fc-alpha-R) is a type I transmembrane glycoprotein serving as a receptor for IgA. Soluble CD89 is detectable in serum and retains its IgA binding capacity. For signal transduction the association with FcR gamma chain homodimers is needed. CD89 is expressed on granulocytes, monocytes, macrophages, dendritic cells and myeloid cell lines. Its expression is upregulated in presence of IgA immune complexes, stimulators (such as LPS, PMA), TNF alpha, IL1 beta or GM-CSF, and it is downregulated in presence of TGF beta and suramin. Binding of IgA-opsonized targets to CD89 leads to phagocytic and cytotoxic processes of the immunologic defense.,FcalphaRI, FcAR, CTB-61M7.2
    Gen-ID
    2204
    UniProt
    P24071
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