tau Antikörper (AA 150-220)

Produktnummer ABIN4902336

Produktdetails anti-tau Antikörper

Target: tau (tau Protein)

Bindungsspezifität: AA 150-220

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser tau Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Tau is a protein encoded by the MAPT gene which is approximately 78,9 kDa. Tau is localised to the cytoplasm and cell membrane. It is involved in the apoptotic cleavage of cellular proteins, MAPK signalling pathway, CDK-mediated phosphorylation and removal of Cdc6 and development slit-robo signalling. It promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein. Tau is expressed in neurons. Mutations in the MAPT gene may result in Frontotemporal dementia. STJ98827 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Tau protein.

Spezifität: The antibody detects endogenous Tau.

Produktmerkmale: Rabbit Polyclonal to Tau.

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthetic peptide from human Tau protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000
ELISA 1:5000-20000

Kommentare:

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS,  pH 7.4, containing 0.02 % sodium azide as Preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu tau

Target: tau (tau Protein)

Andere Bezeichnung: Tau (tau Produkte)

Synonyme: DDPAC antikoerper, FTDP-17 antikoerper, MAPTL antikoerper, MSTD antikoerper, MTBT1 antikoerper, MTBT2 antikoerper, PPND antikoerper, TAU antikoerper, tau antikoerper, PHF-tau antikoerper, microtubule associated protein tau antikoerper, MAPT antikoerper

Molekulargewicht: 80kDa

Gen-ID: 4137

UniProt: P10636