Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

FHIT Antikörper

FHIT Reaktivität: Human WB, FACS Wirt: Maus Monoclonal 3C2 unconjugated
Produktnummer ABIN4909573
  • Target Alle FHIT Antikörper anzeigen
    FHIT (Fragile Histidine Triad (FHIT))
    Reaktivität
    • 84
    • 25
    • 11
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 81
    • 8
    Maus
    Klonalität
    • 81
    • 8
    Monoklonal
    Konjugat
    • 33
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser FHIT Antikörper ist unkonjugiert
    Applikation
    • 41
    • 33
    • 26
    • 26
    • 14
    • 10
    • 8
    • 6
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein G.
    Immunogen
    This FHIT antibody is generated from a mouse immunized with a recombinant protein.
    Klon
    3C2
    Isotyp
    IgG1
    Top Product
    Discover our top product FHIT Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    FCM 1:20-100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    FHIT (Fragile Histidine Triad (FHIT))
    Andere Bezeichnung
    FHIT (FHIT Produkte)
    Synonyme
    AP3Aase antikoerper, FRA3B antikoerper, FHIT antikoerper, zgc:73176 antikoerper, AW045638 antikoerper, Fra14A2 antikoerper, LOC100223655 antikoerper, fragile histidine triad antikoerper, fragile histidine triad gene antikoerper, fragile histidine triad protein antikoerper, fragile histidine triad L homeolog antikoerper, FHIT antikoerper, Fhit antikoerper, fhit antikoerper, PY07476 antikoerper, fhit.L antikoerper
    Hintergrund

    Synonyms: FRA3B, AP3Aase, Bis(5'-adenosyl)-triphosphatase, AP3A hydrolase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein, FHIT

    Background: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

    Gen-ID
    2272
    UniProt
    P49789
Sie sind hier:
Kundenservice