KAT5 Antikörper (pSer90)

Produktnummer ABIN4911293

Produktdetails anti-KAT5 Antikörper

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Bindungsspezifität: pSer90

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KAT5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human KAT5 around the phosphorylation site of Ser90

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: KAT5 (KAT5 Produkte)

Synonyme: 6121 antikoerper, CG6121 antikoerper, DmEG0007.7 antikoerper, Dmel/TIP60 antikoerper, Dmel\\CG6121 antikoerper, Dmel\\TIP60 antikoerper, EG0007.7 antikoerper, EG:EG0007.7 antikoerper, TIP60 antikoerper, dTIP60 antikoerper, dTip60 antikoerper, dmHAG405 antikoerper, im:6908768 antikoerper, wu:fb55b08 antikoerper, zgc:110752 antikoerper, ESA1 antikoerper, HTATIP antikoerper, HTATIP1 antikoerper, PLIP antikoerper, TIP antikoerper, ZC2HC5 antikoerper, cPLA2 antikoerper, AI839539 antikoerper, CPLA2 antikoerper, Htatip antikoerper, Htatip1 antikoerper, Tip55 antikoerper, Tip60 antikoerper, K(lysine) acetyltransferase 5a antikoerper, lysine acetyltransferase 5 antikoerper, Tat interactive protein 60kDa antikoerper, histone acetyltransferase Tip60 antikoerper, tip60, putative antikoerper, K(lysine) acetyltransferase 5b antikoerper, K(lysine) acetyltransferase 5 antikoerper, kat5a antikoerper, KAT5 antikoerper, Tip60 antikoerper, LOC413101 antikoerper, LOC5579231 antikoerper, Smp_053140 antikoerper, kat5b antikoerper, Kat5 antikoerper

Hintergrund:

Synonyms: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5

Background: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Gen-ID: 10524

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway