MASTL Antikörper

Produktnummer ABIN4911795

Produktdetails anti-MASTL Antikörper

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MASTL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This MASTL monoclonal antibody is generated from mouse immunized with MASTL recombinant protein.

Klon: 5C3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu MASTL

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Andere Bezeichnung: MASTL (MASTL Produkte)

Hintergrund:

Synonyms: GW, GWL, THC2, MAST-L, GREATWALL, Serine/threonine-protein kinase greatwall, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MASTL

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Gen-ID: 84930

UniProt: Q96GX5