C6orf150 Antikörper (AA 1-185)

Produktnummer ABIN4911805

Produktdetails anti-C6orf150 Antikörper

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Bindungsspezifität: AA 1-185

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C6orf150 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein G.

Immunogen: This MB21D1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-185 amino acids from human MB21D1.

Klon: 7E3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Andere Bezeichnung: MB21D1 (C6orf150 Produkte)

Synonyme: C6orf150 antikoerper, cGAS antikoerper, h-cGAS antikoerper, Mab-21 domain containing 1 antikoerper, cyclic GMP-AMP synthase antikoerper, MB21D1 antikoerper, CGAS antikoerper

Hintergrund:

Synonyms: cGAS, h-cGAS, C6orf150, Cyclic GMP-AMP synthase, cGAMP synthase, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1, MB21D1

Background: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).

Gen-ID: 115004

UniProt: Q8N884

Pathways: Activation of Innate immune Response