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Nemo-Like Kinase Antikörper

NLK Reaktivität: Human WB Wirt: Maus Monoclonal 6C1 unconjugated
Produktnummer ABIN4912401
  • Target Alle Nemo-Like Kinase (NLK) Antikörper anzeigen
    Nemo-Like Kinase (NLK)
    Reaktivität
    • 81
    • 35
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 83
    • 3
    Maus
    Klonalität
    • 84
    • 2
    Monoklonal
    Konjugat
    • 26
    • 8
    • 7
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nemo-Like Kinase Antikörper ist unkonjugiert
    Applikation
    • 78
    • 41
    • 26
    • 26
    • 24
    • 16
    • 13
    • 11
    • 10
    • 6
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    Purified His-tagged NLK protein was used to produced this monoclonal antibody.
    Klon
    6C1
    Isotyp
    IgG2a
    Top Product
    Discover our top product NLK Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Nemo-Like Kinase (NLK)
    Andere Bezeichnung
    NLK (NLK Produkte)
    Synonyme
    Amf antikoerper, Gpi1 antikoerper, AI194375 antikoerper, nlk antikoerper, nlkb antikoerper, zgc:111875 antikoerper, Xnlk antikoerper, nlk1 antikoerper, nlk2 antikoerper, NLK antikoerper, nemo-like antikoerper, RGD1561602 antikoerper, glucose-6-phosphate isomerase antikoerper, nemo like kinase antikoerper, nemo-like kinase, type 1 antikoerper, nemo-like kinase L homeolog antikoerper, Nemo-Like kinase antikoerper, nemo-like kinase antikoerper, Gpi antikoerper, NLK antikoerper, Nlk antikoerper, nlk1 antikoerper, nlk.L antikoerper, nlk antikoerper, nemo-like antikoerper
    Hintergrund

    Synonyms: Serine/threonine-protein kinase NLK, Nemo-like kinase, Protein LAK1, NLK, LAK1

    Background: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613).

    Gen-ID
    51701
    UniProt
    Q9UBE8
    Pathways
    Ubiquitin Proteasome Pathway
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