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SLC26A6 Antikörper (AA 431-500)

SLC26A6 Reaktivität: Schwein, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN4914082
  • Target Alle SLC26A6 Antikörper anzeigen
    SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))
    Bindungsspezifität
    • 14
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 431-500
    Reaktivität
    • 21
    • 14
    • 14
    • 2
    • 1
    Schwein, Ratte
    Wirt
    • 31
    • 3
    • 2
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SLC26A6 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 12
    • 12
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Kreuzreaktivität
    Schwein, Ratte
    Homologie
    Mouse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SLC26A6
    Isotyp
    IgG
    Top Product
    Discover our top product SLC26A6 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))
    Andere Bezeichnung
    SLC26A6 (SLC26A6 Produkte)
    Synonyme
    B930010B04Rik antikoerper, CFEX antikoerper, Pat1 antikoerper, MGC81960 antikoerper, SLC26A6 antikoerper, slc26a6 antikoerper, MGC145603 antikoerper, si:dkey-20d21.8 antikoerper, solute carrier family 26 member 6 antikoerper, solute carrier family 26, member 6 antikoerper, solute carrier family 26 member 6 S homeolog antikoerper, anion exchanger SLC26A6 antikoerper, SLC26A6 antikoerper, Slc26a6 antikoerper, slc26a6.S antikoerper, slc26a6 antikoerper
    Hintergrund

    Synonyms: Solute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1, SLC26A6

    Background: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney.

    Gen-ID
    65010
    UniProt
    Q9BXS9
    Pathways
    Dicarboxylic Acid Transport
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