TYRO3 Antikörper

Produktnummer ABIN4914977

Produktdetails anti-TYRO3 Antikörper

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TYRO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus

Aufreinigung: Purified by Protein G.

Immunogen: This Tyro3 antibody is generated from a mouse immunized with a recombinant protein.

Klon: 5A3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Andere Bezeichnung: Tyro3 (TYRO3 Produkte)

Hintergrund:

Synonyms: Brt, Dtk, Rse, Sky, Tif, Etk-2, TK19-2, tk19-1, AI323366, etk2/tyro3, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF, Tyro3

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Gen-ID: 22174

UniProt: P55144

Pathways: RTK Signalweg