FOXA1 Antikörper (AA 372-472)
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- Target Alle FOXA1 Antikörper anzeigen
- FOXA1 (Forkhead Box A1 (FOXA1))
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Bindungsspezifität
- AA 372-472
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser FOXA1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Keine Kreuzreaktivität
- Ratte (Rattus)
- Aufreinigung
- Protein G affinity chromatography
- Immunogen
- A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.
- Klon
- FOXA1-1512
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product FOXA1 Primärantikörper
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- Applikationshinweise
- Optimal dilution of the FOXA1 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/10^6 cells,IF: 1-2 μg/mL,WB: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store the FOXA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Target
- FOXA1 (Forkhead Box A1 (FOXA1))
- Andere Bezeichnung
- FOXA1 (FOXA1 Produkte)
- Synonyme
- HNF3A antikoerper, TCF3A antikoerper, Hnf-3a antikoerper, Hnf3a antikoerper, Tcf-3a antikoerper, Tcf3a antikoerper, fkd7 antikoerper, forkhead-7 antikoerper, HNF3-alpha antikoerper, HNF3alpha antikoerper, fkh2 antikoerper, foxa1 antikoerper, hnf3a antikoerper, tFoxA1 antikoerper, tcf3a antikoerper, xfkh2 antikoerper, fkh antikoerper, FOXA1 antikoerper, Ci-fkh antikoerper, HNF-3a antikoerper, forkhead box A1 antikoerper, forkhead box A1 S homeolog antikoerper, forkhead homolog antikoerper, forkhead box A1 L homeolog antikoerper, FOXA1 antikoerper, Foxa1 antikoerper, foxa1 antikoerper, foxa1.S antikoerper, fkh antikoerper, foxa1.L antikoerper
- Hintergrund
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FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
FOXA1 in breast cancer is highly correlated with ERalpha+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERalpha+ breast cancer, and its expression might identify ERalpha+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERalpha−, breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERalpha−, cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment. [Wiki]
- Gen-ID
- 3169
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis
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