LH alpha Antikörper

Produktnummer ABIN4949777

Produktdetails anti-LH alpha Antikörper

Target: LH alpha (Luteinizing Hormone alpha (LH alpha))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LH alpha Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant full-length human LHa protein was used as the immunogen for the Luteinizing Hormone alpha antibody.

Klon: LHa-756

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Luteinizing Hormone alpha antibody should be determined by the researcher.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Luteinizing Hormone alpha antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu LH alpha

Target: LH alpha (Luteinizing Hormone alpha (LH alpha))

Andere Bezeichnung: Luteinizing Hormone alpha / hCG alpha (LH alpha Produkte)

Hintergrund: This mAb reacts with a protein of ~13  kDa, identified as alpha subunit of Luteinizing Hormone (LH) or Chorionic Gonadotrophin (CG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties. LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.