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PRAS40 Antikörper (AA 227-256)

AKT1S1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3029887
  • Target Alle PRAS40 (AKT1S1) Antikörper anzeigen
    PRAS40 (AKT1S1) (AKT1 Substrate 1 (Proline-Rich) (AKT1S1))
    Bindungsspezifität
    • 15
    • 9
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 227-256
    Reaktivität
    • 82
    • 35
    • 34
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 74
    • 9
    Kaninchen
    Klonalität
    • 73
    • 10
    Polyklonal
    Konjugat
    • 34
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRAS40 Antikörper ist unkonjugiert
    Applikation
    • 61
    • 42
    • 28
    • 14
    • 14
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität (Details)
    Expected species reactivity: Mouse
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 227-256 from the human protein was used as the immunogen for this AKT1S1 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product AKT1S1 Primärantikörper
  • Applikationshinweise
    Titration of the AKT1S1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the AKT1S1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PRAS40 (AKT1S1) (AKT1 Substrate 1 (Proline-Rich) (AKT1S1))
    Andere Bezeichnung
    AKT1S1 (AKT1S1 Produkte)
    Synonyme
    MGC81452 antikoerper, lobe antikoerper, pras40 antikoerper, fb34a04 antikoerper, wu:fb34a04 antikoerper, Lobe antikoerper, PRAS40 antikoerper, 1110012J22Rik antikoerper, AI227026 antikoerper, Lobel antikoerper, AKT1 substrate 1 (proline rich) S homeolog antikoerper, AKT1 substrate 1 antikoerper, AKT1 substrate 1 (proline rich) antikoerper, AKT1 substrate 1 (proline-rich) antikoerper, akt1s1.S antikoerper, AKT1S1 antikoerper, akt1s1 antikoerper, Akt1s1 antikoerper
    Hintergrund
    Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection. [UniProt]
    UniProt
    Q96B36
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Autophagie, BCR Signaling, Warburg Effekt
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