SNAIL Antikörper (AA 9-39)

Produktnummer ABIN3032657

Produktdetails anti-SNAIL Antikörper

Target: SNAIL (SNAI1)

Bindungsspezifität: AA 9-39

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Purified

Immunogen: A portion of amino acids 9-39 from the human protein was used as the immunogen for this anti-SNAIL antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the anti-SNAIL antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the anti-SNAIL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu SNAIL

Target: SNAIL (SNAI1)

Abstract: SNAI1 Produkte

Synonyme: SLUGH2 antikoerper, SNA antikoerper, SNAH antikoerper, SNAIL antikoerper, SNAIL1 antikoerper, dJ710H13.1 antikoerper, AI194338 antikoerper, Sna antikoerper, Sna1 antikoerper, Snail antikoerper, Snail1 antikoerper, SNAI1 antikoerper, BG:DS01845.1 antikoerper, CG3956 antikoerper, Dmel\\CG3956 antikoerper, Sco antikoerper, br28 antikoerper, br29 antikoerper, l(2)35Db antikoerper, l(2)br28 antikoerper, l(2)br29 antikoerper, l(3)br28 antikoerper, l35Db antikoerper, sn antikoerper, Xsnail antikoerper, sna antikoerper, snail1 antikoerper, xSna antikoerper, Snai antikoerper, sna2 antikoerper, snail2 antikoerper, cb643 antikoerper, sna-1 antikoerper, sna1 antikoerper, snai1 antikoerper, snail1a antikoerper, zgc:109820 antikoerper, snail family transcriptional repressor 1 antikoerper, snail family zinc finger 1 antikoerper, snail homolog 1 (Drosophila) antikoerper, snail antikoerper, zinc-finger transcription factor Snail antikoerper, snail family zinc finger 1 S homeolog antikoerper, protein escargot antikoerper, transcription factor protein antikoerper, snail zinc finger protein antikoerper, snail family zinc finger 1b antikoerper, snail family zinc finger 1a antikoerper, SNAI1 antikoerper, Snai1 antikoerper, sna antikoerper, snail antikoerper, snai1.S antikoerper, LOC410464 antikoerper, snai1b antikoerper, snai1a antikoerper

Hintergrund: The Drosophila embryonic protein SNAI1, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. SNAI1 zinc-fingers (ZF) binds to E-box, an E-cadherin promoter region, and represses the expression of the adhesion molecule, which induces the tightly bound epithelial cells to break loose from each other and migrate into the developing embryo to become mesenchymal cells. This process allows for the formation of the mesodermal layer in the developing embryo. Though SNAI1 is shown to repress expression of E-cadherin in epithelial cells, studies have shown homozygous mutant embryos are still able to form a mesodermal layer. However, the mesodermal layer present shows characteristics of epithelial cells and not mesenchymal cells (the mutant mesoderm cells exhibited a polarized state). Other studies show that mutation of specific ZFs contribute to a decrease in SNAI1 E-cadherin repression. [Wiki]

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling