ATG5 Antikörper (AA 1-30)

Produktnummer ABIN3030038

Produktdetails anti-ATG5 Antikörper

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Bindungsspezifität: AA 1-30

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität (Details): Expected species reactivity: Rat, Bovine, Pig

Aufreinigung: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this ATG5 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the ATG5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:200,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ATG5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu ATG5

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Andere Bezeichnung: ATG5 (ATG5 Produkte)

Synonyme: APG5 antikoerper, APG5-LIKE antikoerper, APG5L antikoerper, ASP antikoerper, hAPG5 antikoerper, ATG5 antikoerper, CG1643 antikoerper, DmAtg5 antikoerper, Dmel\\CG1643 antikoerper, atg5 antikoerper, 2010107M05Rik antikoerper, 3110067M24Rik antikoerper, AW319544 antikoerper, Apg5l antikoerper, Atg5l antikoerper, C88337 antikoerper, Paddy antikoerper, apg5l antikoerper, zgc:100934 antikoerper, ATATG5 antikoerper, AUTOPHAGY 5 antikoerper, MKP11.20 antikoerper, MKP11_20 antikoerper, autophagy related 5 antikoerper, Autophagy-related 5 antikoerper, ATG5 autophagy related 5 homolog (S. cerevisiae) antikoerper, autophagy related 5 L homeolog antikoerper, similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 antikoerper, autophagy protein Apg5 family antikoerper, ATG5 antikoerper, Atg5 antikoerper, atg5 antikoerper, atg5.L antikoerper, APG5 antikoerper

Hintergrund: ATG5 is involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12/ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12/5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. [UniProt]

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagie