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AXIN2 Antikörper (AA 816-843)

AXIN2 Reaktivität: Human WB, IHC, ELISA, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3030089
  • Target Alle AXIN2 Antikörper anzeigen
    AXIN2 (Axin 2 (AXIN2))
    Bindungsspezifität
    • 15
    • 13
    • 11
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 816-843
    Reaktivität
    • 70
    • 53
    • 40
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 83
    • 2
    Kaninchen
    Klonalität
    • 74
    • 11
    Polyklonal
    Konjugat
    • 24
    • 8
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AXIN2 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 37
    • 29
    • 13
    • 13
    • 13
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    Kreuzreaktivität (Details)
    Expected species reactivity: Mouse, Rat
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product AXIN2 Primärantikörper
  • Applikationshinweise
    Titration of the AXIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the AXIN2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    AXIN2 (Axin 2 (AXIN2))
    Andere Bezeichnung
    AXIN2 (AXIN2 Produkte)
    Synonyme
    AXIL antikoerper, ODCRCS antikoerper, axil antikoerper, wu:fb37c08 antikoerper, zgc:111942 antikoerper, axin-2 antikoerper, xarp antikoerper, MGC81576 antikoerper, arp-A antikoerper, axin2 antikoerper, Axi1 antikoerper, Axil antikoerper, Conductin antikoerper, axin 2 antikoerper, axin 2 (conductin, axil) antikoerper, axin 2 (conductin, axil) S homeolog antikoerper, AXIN2 antikoerper, axin2 antikoerper, axin2.S antikoerper, Axin2 antikoerper
    Hintergrund
    The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
    UniProt
    Q9Y2T1
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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