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Cyclin D1 Antikörper (AA 68-97)

Name: Cyclin D1 Antikörper (AA 68-97)
SKU: ABIN3030588
Price: 628.5 EUR
Availability: InStock

CCND1 Reaktivität: Human, Maus WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of Cyclin D1 antibody and mouse lung lysate. (Cyclin D1 Antikörper (AA 68-97))

IHC analysis of FFPE human breast carcinoma tissue stained with Cyclin D1 antibody (Cyclin D1 Antikörper (AA 68-97))

IHC

IHC analysis of FFPE human testis tissue stained with Cyclin D1 antibody (Cyclin D1 Antikörper (AA 68-97))

IHC

Confocal immunofluorescent analysis of Cyclin D1 antibody with HeLa cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Cyclin D1 Antikörper (AA 68-97))

IHC

7 Abbildungen

Produktnummer ABIN3030588

Datenblatt (PDF)

Target Alle Cyclin D1 (CCND1) Antikörper anzeigen

Cyclin D1 (CCND1)
Bindungsspezifität
22

22

16

16

12

11

9

9

8

7

7

7

6

6

5

5

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 68-97
Reaktivität
236

127

122

40

20

18

16

12

10

9

4

3

3

3

3

2

2

1

1

1

1

1

1
Human, Maus
Wirt
202

56

1
Kaninchen
Passende Sekundärantikörper
Klonalität
192

65
Polyklonal
Konjugat
118

26

20

9

7

5

5

5

5

5

5

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
Dieser Cyclin D1 Antikörper ist unkonjugiert
Applikation
197

86

64

63

40

31

28

27

24

20

20

13

6

5

3

2

2

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität (Details)

Expected species reactivity: Bovine

Aufreinigung

Antigen affinity purified

Immunogen

A portion of amino acids 68-97 from the human protein was used as the immunogen for this Cyclin D1 antibody.

Isotyp

Ig Fraction

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Applikationshinweise

Titration of the Cyclin D1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Aliquot the Cyclin D1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target

Cyclin D1 (CCND1)

Abstract

CCND1 Produkte

Synonyme

BCL1 antikoerper, D11S287E antikoerper, PRAD1 antikoerper, U21B31 antikoerper, AI327039 antikoerper, CycD1 antikoerper, Cyl-1 antikoerper, bcl-1 antikoerper, cD1 antikoerper, cb161 antikoerper, cycd1 antikoerper, etID37810.7 antikoerper, fb52e01 antikoerper, fc45c08 antikoerper, fc83a12 antikoerper, id:ibd1198 antikoerper, wu:fb52e01 antikoerper, wu:fc45c08 antikoerper, wu:fc83a12 antikoerper, ccnd1b antikoerper, prad1 antikoerper, ccnd1 antikoerper, ccnd1a antikoerper, bcl1 antikoerper, d11s287e antikoerper, u21b31 antikoerper, CCND1 antikoerper, cyclin D1 antikoerper, cyclin D1 S homeolog antikoerper, cyclin D1 L homeolog antikoerper, CCND1 antikoerper, Ccnd1 antikoerper, ccnd1 antikoerper, ccnd1.S antikoerper, ccnd1.L antikoerper

Hintergrund

CCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. CyclinD-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. [UniProt]

UniProt

P24385

Pathways

PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling