CYP2E1
Reaktivität: Human
WB, IP
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Titration of the CYP2E1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the CYP2E1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
CYP2E1
(Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))
CYP2E1 antikoerper, CYP2E antikoerper, CYPIIE1 antikoerper, CPE1 antikoerper, P450-J antikoerper, P450C2E antikoerper, Cyp2e antikoerper, cytochrome P450, family 2, subfamily E, polypeptide 1 antikoerper, cytochrome P450 2E1 antikoerper, cytochrome P450 2E1-like antikoerper, cytochrome P450 family 2 subfamily E member 1 antikoerper, cytochrome P450, family 2, subfamily e, polypeptide 1 antikoerper, CYP2E1 antikoerper, PTRG_07411 antikoerper, LOC100342572 antikoerper, LOC100727914 antikoerper, LOC101843716 antikoerper, Cyp2e1 antikoerper
Hintergrund
CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.