DR1 Antikörper (AA 83-112)

Produktnummer ABIN3029101

Produktdetails anti-DR1 Antikörper

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Bindungsspezifität: AA 83-112

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): Expected species reactivity: Rat, Chicken

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 83-112 from the human protein was used as the immunogen for this DR1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the DR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu DR1

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Andere Bezeichnung: DR1 (Down-Regulator of Transcription 1) (DR1 Produkte)

Hintergrund: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

UniProt: Q01658