FGFR4 Antikörper (AA 24-55)

Produktnummer ABIN3030958

Produktdetails anti-FGFR4 Antikörper

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Bindungsspezifität: AA 24-55

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 24-55 from the human protein was used as the immunogen for this FGFR4 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the FGFR4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:200,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the FGFR4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Andere Bezeichnung: FGFR4 (FGFR4 Produkte)

Synonyme: FGFR4 antikoerper, XFGFR-4 antikoerper, XFGFR-4a antikoerper, cd334 antikoerper, fgfr-4 antikoerper, jtk2 antikoerper, tkf antikoerper, xfgfr4 antikoerper, CD334 antikoerper, JTK2 antikoerper, TKF antikoerper, Fgfr-4 antikoerper, etID309818.21 antikoerper, wu:fc13h10 antikoerper, zgc:111935 antikoerper, fgfr-4c antikoerper, fgfr4 antikoerper, fibroblast growth factor receptor 4 antikoerper, fibroblast growth factor receptor 4 S homeolog antikoerper, FGFR4 antikoerper, fgfr4 antikoerper, Fgfr4 antikoerper, fgfr4.S antikoerper

Hintergrund: FGFR4 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR-4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR-4. Mutations that lead to constitutive kinase activation or impair normal FGFR-4 inactivation lead to aberrant signaling. [UniProt]

UniProt: P22455

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding