IgD Antikörper (AA 37-64)

Produktnummer ABIN3031288

Produktdetails anti-IgD Antikörper

Target: IgD

Bindungsspezifität: AA 37-64

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IgD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Purified

Immunogen: A portion of amino acids 37-64 from the human protein was used as the immunogen for this IGHD antibody.

Klon: 607CT8-4-4

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Titration of the IGHD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the IGHD antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu IgD

Target: IgD

Andere Bezeichnung: IGHD (IgD Produkte)

Synonyme: IgD antikoerper, Igh-5 antikoerper, immunoglobulin heavy constant delta antikoerper, immunoglobulin delta heavy chain constant region antikoerper, Ighd antikoerper, Igd antikoerper, IGHD antikoerper

Substanzklasse: Antibody

Hintergrund: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

UniProt: P01880