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LIN28B Antikörper (AA 95-128)

LIN28B Reaktivität: Human WB, ELISA, IHC, FACS, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3031627
  • Target Alle LIN28B Antikörper anzeigen
    LIN28B (Lin-28 Homolog B (LIN28B))
    Bindungsspezifität
    • 11
    • 8
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-128
    Reaktivität
    • 52
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 51
    • 1
    • 1
    Kaninchen
    Klonalität
    • 51
    • 2
    Polyklonal
    Konjugat
    • 32
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LIN28B Antikörper ist unkonjugiert
    Applikation
    • 38
    • 24
    • 24
    • 22
    • 20
    • 6
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
    Kreuzreaktivität (Details)
    Expected species reactivity: Mouse
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 95-128 from the human protein was used as the immunogen for this LIN28B antibody.
    Isotyp
    Ig Fraction
  • Applikationshinweise
    Titration of the LIN28B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the LIN28B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LIN28B (Lin-28 Homolog B (LIN28B))
    Andere Bezeichnung
    LIN28B (LIN28B Produkte)
    Synonyme
    csdd2 antikoerper, LIN-28 antikoerper, CSDD2 antikoerper, 2810403D23Rik antikoerper, D030047M17Rik antikoerper, Lin-28.2 antikoerper, lin-28 homolog B antikoerper, lin-28 homolog B S homeolog antikoerper, lin-28 homolog B (C. elegans) antikoerper, LIN28B antikoerper, lin28b antikoerper, lin28b.S antikoerper, Lin28b antikoerper
    Hintergrund
    LIN28B is a suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation. This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent. Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). [UniProt]
    UniProt
    Q6ZN17
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