LRP6 Antikörper (AA 1531-1560)

Produktnummer ABIN3028807

Produktdetails anti-LRP6 Antikörper

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Bindungsspezifität: AA 1531-1560

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Purified

Immunogen: A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the LRP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the LRP6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Andere Bezeichnung: LRP6 (LRP6 Produkte)

Synonyme: lrp6-A antikoerper, Xlrp6 antikoerper, adcad2 antikoerper, lrp6 antikoerper, LRP6 antikoerper, ADCAD2 antikoerper, C030016K15Rik antikoerper, Cd antikoerper, Gw antikoerper, LDL receptor related protein 6 antikoerper, LDL receptor related protein 6 L homeolog antikoerper, LDL receptor related protein 6 S homeolog antikoerper, low density lipoprotein receptor-related protein 6 antikoerper, low-density lipoprotein receptor-related protein 6 antikoerper, LRP6 antikoerper, lrp6.L antikoerper, lrp6.S antikoerper, lrp6 antikoerper, Lrp6 antikoerper, LOC590395 antikoerper

Hintergrund: LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

UniProt: O75581

Pathways: WNT Signalweg, Tube Formation